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Home » Fighting Alzheimer's » Clinical Trial Shows a Safe New Brain Health Supplement Improves Human Cognition

Millions of Americans suffer from age-related cognitive decline, but a successful clinical trial of a new brain health supplement holds promise for those struggling with cognitive impairment.

You’ve probably noticed that as you’ve gotten older, your memory isn’t what it used to be. You might find yourself forgetting where you put your keys, or struggling to remember someone’s name or finish your crossword puzzle. While this may seem like part of normal aging, it doesn’t mean that it should be ignored.

The problem of cognitive impairment

For most people, certain aspects of cognition start to decline in their mid-to-late 30s. This decline is due to a variety of factors, including the depletion of certain brain nutrients, which leads to a reduction of connections between brain cells, called neurons. For some, this cognitive decline begins to accelerate later in life and can be an early sign of dementia. According to recent estimates, as many as 16 million Americans are currently living with some form of age-related cognitive impairment. This number is growing rapidly, owing in part to the aging baby boomer generation as well as new medical advances that are helping people live longer.

Sadly, there is no cure for cognitive impairment, which is characterized by problems remembering, learning new things, concentrating or making decisions. Medications are available to help improve attention or memory. However, these medications don’t work for everyone, have unwanted side effects, and may only slow cognitive decline temporarily. There are also supplements that claim to reverse memory loss and improve focus. Unfortunately, the majority of these claims have never been substantiated by human clinical trials, and are often based on only a handful of animal studies. Most supplement companies that claim to have tested their products in human clinical trials have never published their results in peer-reviewed medical journals, likely because their data were not convincing to unbiased expert scientists and doctors.

A new brain health supplement offers fresh optimism

Now, a new supplement is offering a ray of hope to the millions of people suffering with age-related cognitive decline.  The supplement is called L-TAMS (sold under the name ClariMem), and is a nutrient complex that was developed through 20 years of research by teams of scientists at MIT, Tsinghua University and Stanford University, among others. Those scientists were studying ways to increase connections between brain cells to improve learning and memory when they discovered that L-TAMS is a critical factor controlling the number of these connections.

L-TAMS can replenish essential brain nutrients that decline as we age, the loss of which is associated with the reduction of neuronal connections and increased cognitive impairment. Several studies in laboratory animals showed that L-TAMS can enter the brain to rebuild and strengthen neuronal connections, and improve learning and memory. But the next step was to show that L-TAMS also works in humans.

Impressive clinical trial results

The remarkable effects of L-TAMS in laboratory animals were recently confirmed in a gold standard clinical trial of older adults with cognitive impairment. The results of that double-blind, placebo-controlled clinical trial were published in the Journal of Alzheimer’s Disease, a respected peer-reviewed medical journal. In the trial, ClariMem (referred to by the clinical code MMFS-01 in the study) substantially improved overall cognitive performance compared to the placebo after just 12 weeks of twice-daily use. Amazingly, the data also indicated that ClariMem improved brain age by 9 years, on average.

Almost as important as its potency is the fact that the supplement is safe. In the clinical trial, there were fewer negative side effects in subjects taking ClariMem than in subjects taking a placebo (inactive sugar pill). The FDA has already acknowledged the safety of L-TAMS, clearing it for human use. In fact, tens of thousands of people are taking L-TAMS every year. In addition to improved cognition, many of these customers have also reported benefits in sleep quality and mood, which also deteriorate as neuronal connections are lost. Additional clinical trials are currently underway to test these effects. 

To learn more about the published clinical trial results, the science behind L-TAMS and upcoming clinical trials, visit

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